Rapid Induction and Maintenance of Virus-Specific CD8⁺ T_EMRA and CD4⁺ T_EM Cells Following Protective Vaccination Against Dengue Virus Challenge in Humans.

ABSTRACT: Dengue virus (DENV) is a mosquito-borne flavivirus that causes serious human disease. The current lack of an effective vaccine to simultaneously protect against the four serotypes of DENV in seronegative individuals is a major unmet medical need. Further, the immunological basis for protective immunity in the setting of DENV infection or vaccination is not fully understood. Our team has developed a live attenuated tetravalent dengue virus vaccine that provides complete protection in a human model of dengue virus challenge. The goal of this study was to define, in the context of protective human vaccination, the quality of vaccine-induced DENV-specific CD8⁺ and CD4⁺ T cells and the temporal dynamics associated with their formation and maintenance. Multifunctional, DENV

SUBMITTER: Graham N 

PROVIDER: S-EPMC7105617 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature