Galanin System in Human Glioma and Pituitary Adenoma.

ABSTRACT: Expression of neuropeptides and their corresponding receptors has been demonstrated in different cancer types, where they can play a role in tumor cell growth, invasion, and migration. Human galanin (GAL) is a 30-amino-acid regulatory neuropeptide which acts through three G protein-coupled receptors, GAL₁-R, GAL₂-R, and GAL₃-R that differ in their signal transduction pathways. GAL and galanin receptors (GALRs) are expressed by different tumors, and direct involvement of GAL in tumorigenesis has been shown. Despite its strong expression in the central nervous system (CNS), the role of GAL in CNS tumors has not been extensively studied. To date, GAL peptide expression, GAL receptor binding and mRNA expression have been reported in glioma, meningioma, and pitu

SUBMITTER: Falkenstetter S 

PROVIDER: S-EPMC7105811 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature