Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: individual patient data meta-analysis.

ABSTRACT:

Background

After a 1999 National Cancer Institute (NCI) clinical alert was issued, chemoradiotherapy has become widely used in treating women with cervical cancer. Two subsequent systematic reviews found that interpretation of the benefits was complicated and some important clinical questions were unanswered.

Objectives

We initiated a meta-analysis seeking updated individual patient data (IPD) from all randomised controlled trials (RCTs) to assess the effect of chemoradiotherapy on all outcomes. We pre-specified analyses to investigate whether the effect of chemoradiotherapy differed by trial or patient characteristics.

Search strategy

We supplemented MEDLINE, LILACS and CANCERLIT searches with information from trial registers, by handsearching relevant meeting procee

SUBMITTER: Chemoradiotherapy for Cervical Cancer Meta-analysis Collaboration (CCCMAC) 

PROVIDER: S-EPMC7105912 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature