Potential Role of Macrophage Migration Inhibitory Factor in the Pathogenesis of Marek's Disease.

ABSTRACT:

Introduction

Marek's disease virus (MDV) can cause malignant T-cell lymphomas and immunosuppression in chickens. Macrophage migration inhibitory factor (MIF) not only plays a critical role in inhibiting T-cell responses, but also contributes to multiple aspects of tumour progression. The aim of this study was to reveal the potential role of MIF in the pathogenesis of MDV infection.

Material and methods

MIF gene expression levels were measured by using real-time PCR. Expression was assayed at different times in chicken embryo fibroblast (CEF) cells and tissue samples of SPF chickens infected with different MDV strains and fold change was calculated by the 2^-△△CT method.

Results

The expression of MIF was significantly downregulated (p < 0.05 and FC > 2) in CE

SUBMITTER: Fan Z 

PROVIDER: S-EPMC7105991 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature