A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken.

ABSTRACT: Coronaviruses are a hot research topic because they can cause severe diseases in humans and animals. Infectious bronchitis virus (IBV), belonging to gamma-coronaviruses, causes a highly infectious respiratory viral disease and can result in catastrophic economic losses to the poultry industry worldwide. Unfortunately, the genetic basis of the host immune responses against IBV is poorly understood. In the present study, the antibody levels against IBV post-immunization were measured by an enzyme-linked immunosorbent assay in the serum of 511 individuals from a commercial chicken (Gallus gallus) population. A genome-wide association study using 43,211 single nucleotide polymorphism markers was performed to identify the major loci affecting the immune response against IBV. This study detected

SUBMITTER: Luo C 

PROVIDER: S-EPMC7106259 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature