The impact of within-herd genetic variation upon inferred transmission trees for foot-and-mouth disease virus.

ABSTRACT: Full-genome sequences have been used to monitor the fine-scale dynamics of epidemics caused by RNA viruses. However, the ability of this approach to confidently reconstruct transmission trees is limited by the knowledge of the genetic diversity of viruses that exist within different epidemiological units. In order to address this question, this study investigated the variability of 45 foot-and-mouth disease virus (FMDV) genome sequences (from 33 animals) that were collected during 2007 from eight premises (10 different herds) in the United Kingdom. Bayesian and statistical parsimony analysis demonstrated that these sequences exhibited clustering which was consistent with a transmission scenario describing herd-to-herd spread of the virus. As an alternative to analysing all of the available

SUBMITTER: Valdazo-Gonzalez B 

PROVIDER: S-EPMC7106308 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature