Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV.

ABSTRACT:

Background

Human rhinovirus (RV) is the most common respiratory virus and has been associated with frequent and severe acute lower respiratory infections (ALRI). The prevalence of RV species among HIV-infected children in South Africa is unknown.

Objectives

To describe the prevalence of respiratory viruses, including RV species, associated with HIV status and other clinical symptoms in children less than two years of age with and without ALRI in Pretoria, South Africa.

Study design

Nasopharyngeal aspirates were collected from 105 hospitalized ALRI cases and 53 non-ALRI controls less than two years of age. HIV status was determined. Common respiratory viruses were identified by PCR, and RV species and genotypes were identified by semi-nested PCR, sequencing and phyloge

SUBMITTER: Annamalay AA 

PROVIDER: S-EPMC7106452 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature