Reliable typing of MERS-CoV variants with a small genome fragment.

ABSTRACT:

Background

Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging pathogen that causes lower respiratory tract infection in humans. Camels are the likely animal source for zoonotic infection, although exact transmission modes remain to be determined. Human-to-human transmission occurs sporadically. The wide geographic distribution of MERS-CoV among dromedary camels and ongoing transmissions to humans provides concern for the evolution of a MERS-CoV variant with efficient human-to-human transmission capabilities. Phylogenetic analysis of MERS-CoV has occurred by analysis of full-length genomes or multiple concatenated genome fragments, which is time-consuming, costly and limited to high viral load samples.

Objective

To develop a simple, reliable MERS-CoV varia

SUBMITTER: Smits SL 

PROVIDER: S-EPMC7106551 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature