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Epstein-Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies.

ABSTRACT: New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere of excitement in the MS community. B cells are now known to play a major role in disease, demonstrated by the highly impactful effect of a B cell-depleting antibody on controlling MS. The idea that a virus may play a role in the development of MS has a long history and is supported mostly by studies demonstrating a link between B cell-tropic Epstein-Barr virus (EBV) and disease onset. Efforts to develop antiviral strategies for treating MS are underway. Although gaps remain in our understanding of the etiology of MS, the role, if any, of viruses in propagating pathogenic immune responses deserves attention.

SUBMITTER: Bar-Or A

PROVIDER: S-EPMC7106557 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Epstein-Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies.

Bar-Or Amit A Pender Michael P MP Khanna Rajiv R Steinman Lawrence L Hartung Hans-Peter HP Maniar Tap T Croze Ed E Aftab Blake T BT Giovannoni Gavin G Joshi Manher A MA

Trends in molecular medicine 20191217 3

New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere of excitement in the MS community. B cells are now known to play a major role in disease, demonstrated by the highly impactful effect of a B cell-depleting antibody on controlling MS. The idea that a virus may play a role in the development of MS has a long history and is supported mostly by studies demonstrating a link between B cell-tropic Epstein-Barr virus (EBV) and disease onset. Efforts to develop anti ...[more]

PMID: 31862243

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