Dataset Information

Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study.

ABSTRACT:

Background

Higher choline and betaine levels have been linked to lower risk of liver cancer, whereas existing data in relation to hepatocellular carcinoma (HCC) prognosis are scarce. Our objective was to examine the associations of the serum choline and betaine with HCC survival.

Methods

866 newly diagnosed HCC patients were enrolled in the Guangdong Liver Cancer Cohort. Serum choline and betaine were assessed using high-performance liquid chromatography with online electro-spray ionization tandem mass spectrometry. Liver cancer-specific survival (LCSS) and overall survival (OS) were calculated. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

Serum choline levels were associated with better LCSS (T3 vs. T1: HR = 0.69, 95% CI: 0.51-0.94; P _-trend < 0.05) and OS (T3 vs. T1: HR = 0.73, 95% CI: 0.54-0.99; P _-trend < 0.05). The associations were significantly modified by C-reactive protein (CRP) levels but not by other selected prognostic factors including sex, age, etc. The favorable associations between serum choline and LCSS and OS were only existed among patients with CRP ≥3.0 mg/L. No significant associations were found between serum betaine levels and either LCSS or OS.

Conclusions

This study revealed that higher serum choline levels were associated with better HCC survival, especially in HCC patients with systemic inflammation status. No significant associations were found between serum betaine and HCC survival. Our findings suggest the benefits of choline on HCC survival.

Trial registration

The Guangdong Liver Cancer Cohort was registered at clinicaltrials.gov as NCT03297255.

SUBMITTER: Liu ZY

PROVIDER: S-EPMC7106561 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study.

Liu Zhao-Yan ZY Yishake Dinuerguli D Fang Ai-Ping AP Zhang Dao-Ming DM Liao Gong-Cheng GC Tan Xu-Ying XY Zhang Yao-Jun YJ Zhu Hui-Lian HL

Nutrition & metabolism 20200330

<h4>Background</h4>Higher choline and betaine levels have been linked to lower risk of liver cancer, whereas existing data in relation to hepatocellular carcinoma (HCC) prognosis are scarce. Our objective was to examine the associations of the serum choline and betaine with HCC survival.<h4>Methods</h4>866 newly diagnosed HCC patients were enrolled in the Guangdong Liver Cancer Cohort. Serum choline and betaine were assessed using high-performance liquid chromatography with online electro-spray ...[more]

PMID: 32256673

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Dataset Information

Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study.

Background

Methods

Results

Conclusions

Trial registration

Publications

Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study.

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