Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study.

ABSTRACT:

Background

Higher choline and betaine levels have been linked to lower risk of liver cancer, whereas existing data in relation to hepatocellular carcinoma (HCC) prognosis are scarce. Our objective was to examine the associations of the serum choline and betaine with HCC survival.

Methods

866 newly diagnosed HCC patients were enrolled in the Guangdong Liver Cancer Cohort. Serum choline and betaine were assessed using high-performance liquid chromatography with online electro-spray ionization tandem mass spectrometry. Liver cancer-specific survival (LCSS) and overall survival (OS) were calculated. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

Serum choline levels were associated with better LCSS

SUBMITTER: Liu ZY 

PROVIDER: S-EPMC7106561 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature