The A818-6 system as an in-vitro model for studying the role of the transportome in pancreatic cancer.

ABSTRACT:

Background

The human pancreatic cancer cell line A818-6 can be grown in vitro either as a highly malignant, undifferentiated monolayer (ML) or as three-dimensional (3D) single layer hollow spheres (HS) simulating a benign, highly differentiated, duct-like pancreatic epithelial structure. This characteristic allowing A818-6 cells to switch from one phenotype to another makes these cells a unique system to characterize the cellular and molecular modifications during differentiation on one hand and malignant transformation on the other hand. Ion channels and transport proteins (transportome) have been implicated in malignant transformation. Therefore, the current study aimed to analyse the transportome gene expression profile in the A818-6 cells growing as a monolayer or as hollow sph

SUBMITTER: Tawfik D 

PROVIDER: S-EPMC7106758 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature