Sex-specific and shared expression profiles of vulnerability and resilience to trauma in brain and blood.

ABSTRACT:

Background

While post-traumatic stress disorder (PTSD) is defined by behavioral/cognitive symptoms most directly relevant to brain function, it can be considered a systemic disorder characterized by a distinct inability to reinstate homeostasis after trauma.

Methods

In this study, we conducted a secondary analysis of gene expression profiles in key PTSD-relevant tissues, namely blood, amygdala, and hippocampus, from a rat model of PTSD, to identify sex-specific and shared processes associated with individual differences in response to recent trauma exposure.

Results

Our findings suggest both shared and sex-specific mechanisms underlying individual differences associated with vulnerability and resilience to trauma in hippocampus, amygdala, and blood. By disentangling c

SUBMITTER: Kim GS 

PROVIDER: S-EPMC7106761 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature