A key genomic signature associated with lymphovascular invasion in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Lymphovascular invasion (LOI), a key pathological feature of head and neck squamous cell carcinoma (HNSCC), is predictive of poor survival; however, the associated clinical characteristics and underlying molecular mechanisms remain largely unknown.

Methods

We performed weighted gene co-expression network analysis to construct gene co-expression networks and investigate the relationship between key modules and the LOI clinical phenotype. Functional enrichment and KEGG pathway analyses were performed with differentially expressed genes. A protein-protein interaction network was constructed using Cytoscape, and module analysis was performed using MCODE. Prognostic value, expression analysis, and survival analysis were conducted using hub genes; GEPIA and the Human Pr

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7106876 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature