Mechanisms of Berberine for the Treatment of Atherosclerosis Based on Network Pharmacology.

ABSTRACT: Atherosclerosis is a common metabolic disease characterized by lipid metabolic disorder. The processes of atherosclerosis include endothelial dysfunction, new endothelial layer formation, lipid sediment, foam cell formation, plaque formation, and plaque burst. Owing to the adverse effects of first-line medications, it is urgent to discover new medications to deal with atherosclerosis. Berberine is one of the most promising natural products derived from traditional Chinese medicine. However, the panoramic mechanism of berberine against atherosclerosis has not been discovered clearly. In this study, we used network pharmacology to investigate the interaction between berberine and atherosclerosis. We identified potential targets related to berberine and atherosclerosis from several databases.

SUBMITTER: Xie X 

PROVIDER: S-EPMC7106879 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature