Heterotypic Infection and Spread of Rhinovirus A, B, and C among Childcare Attendees.

ABSTRACT:

Background

Despite the frequency of human rhinovirus (HRV), data describing the molecular epidemiology of HRV in the community are limited. Childcare centers are optimal settings to characterize heterotypic HRV cocirculation.

Methods

HRV specimens were prospectively obtained from a cohort of childcare attendees at enrollment and weekly during respiratory illness. The 5' noncoding region sequences were used to determine HRV species (A, B, C) and genotypes.

Results

Among 225 children followed, sequence data were available for 92 HRV infections: HRV-A (n = 80; 59%) was most common, followed by HRV-C (n = 52, 39%), and HRV-B (n = 3, 2%). Forty-one genotypes were identified and cocirculation was common. Frequent spread between classrooms occurred with 2 HRV-A genotypes. Re

SUBMITTER: Martin ET 

PROVIDER: S-EPMC7107396 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature