Timing of First Respiratory Virus Detections in Infants: A Community-Based Birth Cohort Study.

ABSTRACT:

Background

Determining timing of first virus detection episodes (fVDEs) for different respiratory viruses in infants identifies risk periods and informs preventive interventions, including vaccination. We describe the ages and nature of fVDEs in an infant birth cohort and explore factors associated with increased odds of symptomatic fVDEs.

Methods

The Observational Research in Childhood Infectious Diseases (ORChID) study is a community-based birth cohort describing acute respiratory infections in infants until their second birthday. Parents recorded daily symptoms and collected nose swabs weekly, which were batch-tested using polymerase chain reaction assays for 17 respiratory viruses.

Results

One hundred fifty-eight infants participated in ORChID. The median age for

SUBMITTER: Sarna M 

PROVIDER: S-EPMC7107408 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature