Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children.

ABSTRACT:

Background

Severity of human metapneumovirus (hMPV) lower respiratory illness (LRTI) is considered similar to that observed for respiratory syncytial virus (RSV). However, differences in severity between these pathogens have been noted, suggesting the degree of illness may vary in different populations. Moreover, a potential association between hMPV and asthma also suggests that hMPV may preferentially affect asthmatic subjects.

Methods

In a population-based surveillance study in children aged <2 years admitted for severe LRTI in Argentina, nasopharyngeal aspirates were tested by RT-PCR for hMPV, RSV, influenza A, and human rhinovirus.

Results

Of 3947 children, 383 (10%) were infected with hMPV. The hospitalization rate for hMPV LRTI was 2.26 per 1000 children (95% co

SUBMITTER: Libster R 

PROVIDER: S-EPMC7107446 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature