Immune Predictors of Mortality After Ribonucleic Acid Virus Infection.

ABSTRACT:

Background

Virus infections result in a range of clinical outcomes for the host, from asymptomatic to severe or even lethal disease. Despite global efforts to prevent and treat virus infections to limit morbidity and mortality, the continued emergence and re-emergence of new outbreaks as well as common infections such as influenza persist as a health threat. Challenges to the prevention of severe disease after virus infection include both a paucity of protective vaccines as well as the early identification of individuals with the highest risk that may require supportive treatment.

Methods

We completed a screen of mice from the Collaborative Cross (CC) that we infected with influenza, severe acute respiratory syndrome-coronavirus, and West Nile virus.

Results

The CC mi

SUBMITTER: Graham JB 

PROVIDER: S-EPMC7107456 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature