Evaluating the Adequacy of Molecular Clock Models Using Posterior Predictive Simulations.

ABSTRACT: Molecular clock models are commonly used to estimate evolutionary rates and timescales from nucleotide sequences. The goal of these models is to account for rate variation among lineages, such that they are assumed to be adequate descriptions of the processes that generated the data. A common approach for selecting a clock model for a data set of interest is to examine a set of candidates and to select the model that provides the best statistical fit. However, this can lead to unreliable estimates if all the candidate models are actually inadequate. For this reason, a method of evaluating absolute model performance is critical. We describe a method that uses posterior predictive simulations to assess the adequacy of clock models. We test the power of this approach using simulated data and

SUBMITTER: Duchene DA 

PROVIDER: S-EPMC7107558 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature