Vitamin D polygenic score is associated with neuroticism and the general psychopathology factor.

ABSTRACT: Vitamin D, used here to refer to both 25-hydroxyvitamin D, the main circulating form of the vitamin, and 1,25-hydroxyvitamin D, the biologically active form, has been shown to influence brain development and function. Consistent with these findings, low levels of vitamin D have been implicated in various mental disorders, including depression, schizophrenia, and autism. Recently, a shared variance across multiple categories of mental health disorders has been identified and shown to be genetically influenced. This shared variance, thought to represent a general risk for psychopathology, has been termed the p factor. Individuals with high p factor scores are characterized by high neuroticism and low agreeableness and conscientiousness. Here, we investigated the links between vitamin D polyg

SUBMITTER: Avinun R 

PROVIDER: S-EPMC7107583 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature