A comprehensive annotation and differential expression analysis of short and long non-coding RNAs in 16 bat genomes.

ABSTRACT: Although bats are increasingly becoming the focus of scientific studies due to their unique properties, these exceptional animals are still among the least studied mammals. Assembly quality and completeness of bat genomes vary a lot and especially non-coding RNA (ncRNA) annotations are incomplete or simply missing. Accordingly, standard bioinformatics pipelines for gene expression analysis often ignore ncRNAs such as microRNAs or long antisense RNAs. The main cause of this problem is the use of incomplete genome annotations. We present a complete screening for ncRNAs within 16 bat genomes. NcRNAs affect a remarkable variety of vital biological functions, including gene expression regulation, RNA processing, RNA interference and, as recently described, regulatory processes in viral infectio

SUBMITTER: Mostajo NF 

PROVIDER: S-EPMC7108008 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature