An intra-tumoral niche maintains and differentiates stem-like CD8 T cells.

ABSTRACT: Tumour-infiltrating lymphocytes are associated with a survival benefit in several tumour types and with the response to immunotherapy^1-8. However, the reason some tumours have high CD8 T cell infiltration while others do not remains unclear. Here we investigate the requirements for maintaining a CD8 T cell response against human cancer. We find that CD8 T cells within tumours consist of distinct populations of terminally differentiated and stem-like cells. On proliferation, stem-like CD8 T cells give rise to more terminally differentiated, effector-molecule-expressing daughter cells. For many T cells to infiltrate the tumour, it is critical that this effector differentiation process occur. In addition, we show that these stem-like T cells reside in dense antigen-presenting-cell

SUBMITTER: Jansen CS 

PROVIDER: S-EPMC7108171 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature