Throat swabs in children with respiratory tract infection: associations with clinical presentation and potential targets for point-of-care testing.

ABSTRACT:

Background and objectives

Diagnostic uncertainty over respiratory tract infections (RTIs) in primary care contributes to over-prescribing of antibiotics and drives antibiotic resistance. If symptoms and signs predict respiratory tract microbiology, they could help clinicians target antibiotics to bacterial infection. This study aimed to determine relationships between symptoms and signs in children presenting to primary care and microbes from throat swabs.

Methods

Cross-sectional study of children ≥3 months to <16 years presenting with acute cough and RTI, with subset follow-up. Associations and area under receiver operating curve (AUROC) statistics sought between clinical presentation and baseline microbe detection. Microbe prevalence compared between baseline (symptomatic)

SUBMITTER: Thornton HV 

PROVIDER: S-EPMC7108458 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature