Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis.

ABSTRACT:

Background

Viral infections have been suggested as possible triggers for the onset of ulcerative colitis (UC).

Methods

We employed VirCapSeq-Vert, a high-throughput sequencing virus capture platform, to examine the stool virome of children with newly diagnosed moderate to severe UC. We surveyed fecal samples collected at presentation, after symptom remission, and from a control group diagnosed with irritable bowel syndrome.

Results

Seventy subjects with UC (mean age 13 years, 45 had moderate symptoms, 25 had severe, 69 of 70 had a Mayo endoscopy subscore 2/3) were studied. We detected a wide range of animal viruses that were taxonomically classified into 12 viral families. A virus was present in 50% of fecal samples collected at presentation, 41% of samples collected

SUBMITTER: Tokarz R 

PROVIDER: S-EPMC7108593 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature