Polygenic risk for alcohol misuse is moderated by romantic partnerships.

ABSTRACT:

Background and aims

Previous twin research suggests relationship status can moderate underlying genetic liability towards alcohol misuse. This paper examined: (1) whether genome-wide polygenic scores (GPS) for alcohol consumption are associated with alcohol misuse; (2) whether these GPS are moderated by romantic relationships (gene-environment interaction; G × E) and (3) whether G × E results are consistent across sex.

Design

Linear mixed-effects models were used to test associations between genome-wide polygenic scores, relationship status and alcohol use/misuse.

Setting

Finnish twins born between 1983 and 1987 identified through Finland's central population registry.

Participants

An intensively studied subset of Finnish Twin Study (FinnTwin12) during the youn

SUBMITTER: Barr PB 

PROVIDER: S-EPMC7108791 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature