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Impact of community piped water coverage on re-infection with urogenital schistosomiasis in rural South Africa.

ABSTRACT: Previously, we demonstrated that coverage of piped water in the seven years preceding a parasitological survey was strongly predictive of Schistosomiasis haematobium infection in a nested cohort of 1976 primary school children (Tanser, 2018). Here, we report on the prospective follow up of infected members of this nested cohort (N = 333) for two successive rounds following treatment. Using a negative binomial regression fitted to egg count data, we found that every percentage point increase in piped water coverage was associated with 4.4% decline in intensity of re-infection (incidence rate ratio = 0.96, 95% CI: 0.93-0.98, p=0.004) among the treated children. We therefore provide further compelling evidence in support of the scaleup of piped water as an effective control strategy against Schistosoma haematobium transmission.

SUBMITTER: Mogeni P 

PROVIDER: S-EPMC7108860 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Impact of community piped water coverage on re-infection with urogenital schistosomiasis in rural South Africa.

Mogeni Polycarp P   Vandormael Alain A   Cuadros Diego D   Appleton Christopher C   Tanser Frank F  

eLife 20200317

Previously, we demonstrated that coverage of piped water in the seven years preceding a parasitological survey was strongly predictive of <i>Schistosomiasis haematobium</i> infection in a nested cohort of 1976 primary school children (Tanser, 2018). Here, we report on the prospective follow up of infected members of this nested cohort (N = 333) for two successive rounds following treatment. Using a negative binomial regression fitted to egg count data, we found that every percentage point increa  ...[more]