KRT84 is a potential tumor suppressor and good prognosis signature of oral squamous cell carcinoma.

ABSTRACT:

Aims

Oral squamous cell carcinoma (OSCC) is a common oral cancer; however, current therapeutic approaches still show limited efficacy. Our research aims to explore effective biomarkers related to OSCC.

Main methods

Gene expression profiles of paired OSCC tumor and paracancerous samples from The Cancer Genome Atlas (TCGA) were analyzed. mRNA and protein levels of KRT84 in OSCC cell line HSC-3 were measured by real-time quantitative polymerase chain reaction (RT-qPCR) and Western blot. KRT84 protein levels in OSCC tumor samples of different stages were determined by immunohistochemistry. Overall survival (OS) of OSCC samples was evaluated and association of multiple factors with OS was assessed.

Key findings

Compared with paracancerous samples, 4642 DEGs were identified

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7109001 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature