The role of H1 antihistamines in contralateral breast cancer: a Danish nationwide cohort study.

ABSTRACT:

Background

Preclinical studies have shown both pro- and antineoplastic effects of antihistamines. Here, we evaluated the effect of H1 antihistamines on contralateral breast cancer (CBC) risk, and whether cationic amphiphilic (CAD) antihistamines could increase the sensitivity to chemotherapy.

Methods

From the Danish Breast Cancer Group clinical database, we identified all women aged ≥20 years with a first-time diagnosis of breast cancer during 1996-2012. Information on drug use, CBC and potential confounding factors was retrieved from nationwide registries. Using Cox proportional hazard regression models, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for CBC associated with H1-antihistamine use.

Results

We identified 52,723 patients with breast

SUBMITTER: Bens A 

PROVIDER: S-EPMC7109031 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature