Establishing a Causal Role for Medial Prefrontal Cortex in Reality Monitoring.

ABSTRACT: Reality monitoring is defined as the ability to distinguish internally self-generated information from externally-derived information. Functional imaging studies have consistently found that the medial prefrontal cortex (mPFC) is a key brain region subserving reality monitoring. This study aimed to determine a causal role for mPFC in reality monitoring using navigated repetitive transcranial magnetic stimulation (nrTMS). In a subject-blinded sham-controlled crossover design, healthy individuals received either active or sham nrTMS targeting mPFC. Active modulation of mPFC using nrTMS at a frequency of 10 Hz, significantly improved identification of both self-generated and externally-derived information during reality monitoring, when compared to sham or baseline. Targeted excitatory modula

SUBMITTER: Subramaniam K 

PROVIDER: S-EPMC7109326 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature