Oral ethinyl estradiol treatment in women with cystic fibrosis is associated with lower bone mineral density.

ABSTRACT:

Objective

The purpose of this study was to determine whether estrogen supplementation primarily from oral contraceptive pills compared to no estrogen supplementation is associated with differences in mean bone mineral density (BMD) measured by DXA in a cross-sectional study of women with cystic fibrosis (CF).

Methods

In this cross-sectional study of women with CF followed at a single center, we analyzed 49 women with CF ages 18-50 years with a documented DXA. BMD of women with CF taking estrogen supplementation was compared to BMD of women with CF not taking estrogen supplementation.

Results

Twelve women with CF were taking estrogen supplementation with mean dose of 23.3 mcg/day (SD 6.9 mcg/day) of ethinyl estradiol. There were no statistically significant differences

SUBMITTER: Wu M 

PROVIDER: S-EPMC7109452 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature