Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study.

ABSTRACT: In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson's disease. The mechanism of action of this effect of zolpidem is of great research interest. In this case study, we use magnetoencephalography (MEG) to investigate a fully conscious, ex-coma patient who suffered from neurological difficulties for a few years due to traumatic brain injury. For a few years after injury, the patient was under medication with zolpidem that drastically improved his symptoms. MEG recordings taken before and after zolpidem showed a reduction in power in the theta-alpha (4-12 Hz) and lower beta (15-20 Hz) frequency bands. An

SUBMITTER: Sripad P 

PROVIDER: S-EPMC7109561 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature