RUNX3 levels in human hematopoietic progenitors are regulated by aging and dictate erythroid-myeloid balance.

ABSTRACT: Healthy bone marrow progenitors yield a co-ordinated balance of hematopoietic lineages. This balance shifts with aging toward enhanced granulopoiesis with diminished erythropoiesis and lymphopoiesis, changes which likely contribute to the development of bone marrow disorders in the elderly. In this study, RUNX3 was identified as a hematopoietic stem and progenitor cell factor whose levels decline with aging in humans and mice. This decline is exaggerated in hematopoietic stem and progenitor cells from subjects diagnosed with unexplained anemia of the elderly. Hematopoietic stem cells from elderly unexplained anemia patients had diminished erythroid but unaffected granulocytic colony forming potential. Knockdown studies revealed human hematopoietic stem and progenitor cells to be strongly i

SUBMITTER: Balogh P 

PROVIDER: S-EPMC7109730 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature