Review of computational methods for virus-host protein interaction prediction: a case study on novel Ebola-human interactions.

ABSTRACT: Identification of potential virus-host interactions is useful and vital to control the highly infectious virus-caused diseases. This may contribute toward development of new drugs to treat the viral infections. Recently, database records of clinically and experimentally validated interactions between a small set of human proteins and Ebola virus (EBOV) have been published. Using the information of the known human interaction partners of EBOV, our main objective is to identify a set of proteins that may interact with EBOV proteins. Here, we first review the state-of-the-art, computational methods used for prediction of novel virus-host interactions for infectious diseases followed by a case study on EBOV-human interactions. The assessment result shows that the predicted human host proteins

SUBMITTER: Halder AK 

PROVIDER: S-EPMC7109800 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature