RNA-mediated translation regulation in viral genomes: computational advances in the recognition of sequences and structures.

ABSTRACT: RNA structures are widely distributed across all life forms. The global conformation of these structures is defined by a variety of constituent structural units such as helices, hairpin loops, kissing-loop motifs and pseudoknots, which often behave in a modular way. Their ubiquitous distribution is associated with a variety of functions in biological processes. The location of these structures in the genomes of RNA viruses is often coordinated with specific processes in the viral life cycle, where the presence of the structure acts as a checkpoint for deciding the eventual fate of the process. These structures have been found to adopt complex conformations and exert their effects by interacting with ribosomes, multiple host translation factors and small RNA molecules like miRNA. A number o

SUBMITTER: Gupta A 

PROVIDER: S-EPMC7109810 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature