Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital.

ABSTRACT:

Objectives

To describe the immunological responses and clinical outcome of coronavirus (SARS) infected healthcare workers (HCW) who had been administered with convalescent plasma as a treatment.

Methods

Convalescent plasma (500 mL) was obtained from each of three SARS patients and transfused into the three infected HCW. Donors were blood type O and seronegative for hepatitis B and C, HIV, syphilis and human T-cell lymphotropic virus types I and II (HTLV-I and -II). Serum antibody (IgG) titre was >640. Apharesis was performed with a CS 3000 plus cell separator followed by the forming of the convalescent phase plasma. As part of the routine check with donated plasma, the convalescent plasma was confirmed free of residual SARS-CoV by RT-PCR. Serial serum samples obtained from t

SUBMITTER: Yeh KM 

PROVIDER: S-EPMC7110092 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature