Pepitope: epitope mapping from affinity-selected peptides.

ABSTRACT:

Unlabelled

Identifying the epitope to which an antibody binds is central for many immunological applications such as drug design and vaccine development. The Pepitope server is a web-based tool that aims at predicting discontinuous epitopes based on a set of peptides that were affinity-selected against a monoclonal antibody of interest. The server implements three different algorithms for epitope mapping: PepSurf, Mapitope, and a combination of the two. The rationale behind these algorithms is that the set of peptides mimics the genuine epitope in terms of physicochemical properties and spatial organization. When the three-dimensional (3D) structure of the antigen is known, the information in these peptides can be used to computationally infer the corresponding epitope. A user-frie

SUBMITTER: Mayrose I 

PROVIDER: S-EPMC7110138 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature