Control of Energy Transfer Between Pyrene- and Perylene-Nucleosides by the Sequence of DNA-Templated Supramolecular Assemblies.

ABSTRACT: DNA was used as supramolecular scaffold to order chromophores and control their optical properties. Ethynylpyrene as energy donor was attached to 2'-desoxy-2-aminoadenosine that binds selectively to thymidines (T) in the template. Ethynylperylene as acceptor was attached to 2'-desoxyuridine that is complementary to 2'-desoxyadenosine (A). This donor-acceptor pair was assembled along single-stranded DNA templates of different A-T sequences to investigate the sequence control of the energy transfer between the chromophores. The fluorescence intensities increase in the mixed assemblies along the DNA templates from A₁₀T₁₀ over (AATT)₅ to (AT)₁₀, although these templates provide equal numbers of potential binding sites for the two different nucleoside

SUBMITTER: Muller S 

PROVIDER: S-EPMC7110160 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature