Human coronavirus and acute respiratory illness in older adults with chronic obstructive pulmonary disease.

ABSTRACT:

Background

The clinical features and incidence of human coronavirus (HCoV) infections in chronically ill older adults need better definition.

Methods

HCoV infection was determined on the basis of a 4-fold increase in serum antibody and the detection of HCoV by reverse-transcription polymerase chain reaction. Laboratory-documented influenza (LDI) was detected by serologic assay and culture. HCoV illnesses were compared with other acute respiratory illnesses identified by active surveillance, during the 1998-99 winter respiratory-virus season, of 2215 patients with chronic obstructive pulmonary disease who were > or = 50 years old and who received influenza vaccines.

Results

HCoV-229E and HCoV-OC43 were associated with 90 (14%) of 665 illnesses (HCoV-229E in 22, HCoV-OC

SUBMITTER: Gorse GJ 

PROVIDER: S-EPMC7110218 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature