The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry.

ABSTRACT:

Objectives

Filoviruses such as Ebola virus and Marburg virus cause a severe haemorrhagic fever syndrome in humans for which there is no specific treatment. Since filoviruses use a complex route of cell entry that depends on numerous cellular factors, we hypothesized that there may be drugs already approved for human use for other indications that interfere with signal transduction or other cellular processes required for their entry and hence have anti-filoviral properties.

Methods

We used authentic filoviruses and lentiviral particles pseudotyped with filoviral glycoproteins to identify and characterize such compounds.

Results

We discovered that amiodarone, a multi-ion channel inhibitor and adrenoceptor antagonist, is a potent inhibitor of filovirus cell entry at con

SUBMITTER: Gehring G 

PROVIDER: S-EPMC7110251 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature