Modeling the adaptive immune system: predictions and simulations.

ABSTRACT:

Motivation

Immunological bioinformatics methods are applicable to a broad range of scientific areas. The specifics of how and where they might be implemented have recently been reviewed in the literature. However, the background and concerns for selecting between the different available methods have so far not been adequately covered.

Summary

Before using predictions systems, it is necessary to not only understand how the methods are constructed but also their strength and limitations. The prediction systems in humoral epitope discovery are still in their infancy, but have reached a reasonable level of predictive strength. In cellular immunology, MHC class I binding predictions are now very strong and cover most of the known HLA specificities. These systems work well for epi

SUBMITTER: Lundegaard C 

PROVIDER: S-EPMC7110254 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature