Association between intracortical microarchitecture and the compressive fatigue life of human bone: A pilot study.

ABSTRACT: Many mechanical properties of cortical bone are largely governed by the underlying microarchitecture; however, the influence of microarchitecture on the fatigue life of bone is poorly understood. Furthermore, imaging-based studies investigating intracortical microarchitecture may expose bone samples to large doses of radiation that may compromise fatigue resistance. The purpose of this pilot study was to 1) investigate the relationship between intracortical microarchitecture and the fatigue life of human bone in compression and 2) examine the effects of synchrotron irradiation on fatigue life measurements. Cortical samples were prepared from the femoral and tibial shafts of three cadaveric donors. A subset of samples was imaged using synchrotron X-ray microCT to quantify microarchitecture,

SUBMITTER: Loundagin LL 

PROVIDER: S-EPMC7110329 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature