High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea.

ABSTRACT:

Objectives

To explore the epidemiological and clinical factors predictive of the case fatality rate (CFR) of Middle East respiratory syndrome-coronavirus (MERS-CoV) infection in an outbreak in Daejeon, the Republic of Korea.

Methods

We reviewed the outbreak investigation reports and medical records of 1 index case and 25 additional MERS cases in hospitals A (14 cases) and B (11 cases), and conducted an in-depth interview with the index case.

Results

The CFR in hospital B was higher than that in hospital A (63.6% vs. 28.6%, respectively). Higher MERS-CoV exposure conditions were also found in hospital B, including aggravated pneumonia in the index case and nebulizer use in a six-bed admission room. The host factors associated with high CFR were pre-existing pneumonia,

SUBMITTER: Nam HS 

PROVIDER: S-EPMC7110480 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature