Structural Brain Alterations in Youth With Psychosis and Bipolar Spectrum Symptoms.

ABSTRACT:

Objective

Adults with established diagnoses of serious mental illness (bipolar disorder and schizophrenia) exhibit structural brain abnormalities, yet less is known about how such abnormalities manifest earlier in development.

Method

Cross-sectional data publicly available from the Philadelphia Neurodevelopmental Cohort (PNC) were analyzed. Structural magnetic resonance neuroimaging data were collected on a subset of the PNC (N = 989; 9-22 years old). Cortical thickness, surface area (SA), and subcortical volumes were calculated. Study participants were assessed for psychiatric symptomatology using a structured interview and the following groups were created: typically developing (n = 376), psychosis spectrum (PS; n = 113), bipolar spectrum (BP; n = 117), and BP + PS (n = 10

SUBMITTER: Jalbrzikowski M 

PROVIDER: S-EPMC7110691 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature