Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundacio ACE Healthy Brain Initiative.

ABSTRACT:

Background

Optical coherence tomography (OCT) of the retina is a fast and easily accessible tool for the quantification of retinal structural measurements. Multiple studies show that patients with Alzheimer's disease (AD) exhibit thinning in several retinal layers compared to age-matched controls. Subjective cognitive decline (SCD) has been proposed as a risk factor for progression to AD. There is little data about retinal changes in preclinical AD and their correlation with amyloid-β (Aβ) uptake.

Aims

We investigated the association of retinal thickness quantified by OCT with Aβ accumulation and conversion to mild cognitive impairment (MCI) over 24 months in individuals with SCD.

Methods

One hundred twenty-nine individuals with SCD enrolled in Fundació ACE Healthy Br

SUBMITTER: Marquie M 

PROVIDER: S-EPMC7110730 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature