CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related mortality globally. Discovering effective biomarkers for early diagnosis and prognosis is important to reduce the mortality rate and ensure efficient therapy for lung cancer patients. C-type lectin domain family 3 member B (CLEC3B) has been reported in various cancers, but its correlation with lung cancer remains elusive.

Methods

The GEO, TCGA and Oncomine databases were analyzed to examine the expression of CLEC3B in lung cancer. The CLEC3B mRNA levels in 15 patient tissue samples were detected by real-time PCR and the CLEC3B protein levels in 34 patient tissue samples were detected by immunohistochemistry. A Chi-square test was performed to analyze the correlation of CLEC3B expression and clinicopathological fac

SUBMITTER: Sun J 

PROVIDER: S-EPMC7110733 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature