Macrolides in critically ill patients with Middle East Respiratory Syndrome.

ABSTRACT: OBJECTIVES:Macrolides have been reported to be associated with improved outcomes in patients with viral pneumonia related to influenza and other viruses, possibly because of their immune-modulatory effects. Macrolides have frequently been used in patients with Middle East Respiratory Syndrome (MERS). This study investigated the association of macrolides with 90-day mortality and MERS coronavirus (CoV) RNA clearance in critically ill patients with MERS. METHODS:This retrospective analysis of a multicenter cohort database included 14 tertiary-care hospitals in five cities in Saudi Arabia. Multivariate logistic-regression analysis was used to determine the association of macrolide therapy with 90-day mortality, and the Cox-proportional hazard model to determine the association of macrolide th

SUBMITTER: Arabi YM 

PROVIDER: S-EPMC7110878 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature