Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage.

ABSTRACT: In the central nervous system (CNS), innate immune surveillance is mainly coordinated by microglia. These CNS resident myeloid cells are assumed to help orchestrate the immune response against infections of the brain. However, their specific role in this process and their interactions with CNS infiltrating immune cells, such as blood-borne monocytes and T cells are only incompletely understood. The recent development of PLX5622, a specific inhibitor of colony-stimulating factor 1 receptor that depletes microglia, allows studying the role of microglia in conditions of brain injury such as viral encephalitis, the most common form of brain infection. Here we used this inhibitor in a model of viral infection-induced epilepsy, in which C57BL/6 mice are infected by a picornavirus (Theiler's muri

SUBMITTER: Waltl I 

PROVIDER: S-EPMC7111316 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature