The protein interaction networks of mucolipins and two-pore channels.

ABSTRACT:

Background

The endolysosomal, non-selective cation channels, two-pore channels (TPCs) and mucolipins (TRPMLs), regulate intracellular membrane dynamics and autophagy. While partially compensatory for each other, isoform-specific intracellular distribution, cell-type expression patterns, and regulatory mechanisms suggest different channel isoforms confer distinct properties to the cell.

Scope of review

Briefly, established TPC/TRPML functions and interaction partners ('interactomes') are discussed. Novel TRPML3 interactors are shown, and a meta-analysis of experimentally obtained channel interactomes conducted. Accordingly, interactomes are compared and contrasted, and subsequently described in detail for TPC1, TPC2, TRPML1, and TRPML3.

Major conclusions

TPC interactom

SUBMITTER: Krogsaeter EK 

PROVIDER: S-EPMC7111325 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature