Evolution, antigenicity and pathogenicity of global porcine epidemic diarrhea virus strains.

ABSTRACT: Emerging and re-emerging coronaviruses cause morbidity and mortality in human and animal populations, resulting in serious public and animal health threats and economic losses. The ongoing outbreak of a highly contagious and deadly porcine epidemic diarrhea virus (PEDV) in Asia, the Americas and Europe is one example. Genomic sequence analyses of PEDV variants have revealed important insights into the evolution of PEDV. However, the antigenic variations among different PEDV strains are less explored, although they may contribute to the failure of PEDV vaccines in Asian countries. In addition, the evolution of PEDV results in variants with distinct genetic features and virulence differences; thus PEDV can serve as a model to explore the molecular mechanisms of coronavirus evolution and path

SUBMITTER: Lin CM 

PROVIDER: S-EPMC7111424 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature