The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults.

ABSTRACT:

Objective:

Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults.

Methods:

Eighty-seven subjects aged > 55 years were recruited using a community-based convenience sampling strategy

SUBMITTER: Azeredo LA 

PROVIDER: S-EPMC7111449 | biostudies-literature | 2017 Apr-Jun

REPOSITORIES: biostudies-literature